Search results for "Common denominator"

showing 10 items of 10 documents

Metabolic classification and intervention opportunities for tumor energy dysfunction

2021

A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer accordin…

0301 basic medicineEndocrinology Diabetes and MetabolismMetabolic reprogrammingReviewBiologyBioinformaticsBiochemistryMicrobiology03 medical and health sciences0302 clinical medicinetumor reprogrammingmedicinetumor microenvironmentMolecular BiologyTumor ecosystemTumor reprogrammingTumor microenvironmentCancerCommon denominatorMetabolismHypoxia (medical)medicine.diseaseQR1-502Metabolic pathway030104 developmental biologyCell metabolismTumor microenvironment030220 oncology & carcinogenesistumor ecosystemmedicine.symptom
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Fractional calculus in solid mechanics: local versus non-local approach

2009

Several enriched continuum mechanics theories have been proposed by the scientific community in order to develop models capable of describing microstructural effects. The aim of the present paper is to revisit and compare two of these models, whose common denominator is the use of fractional calculus operators. The former was proposed to investigate damage in materials exhibiting a fractal-like microstructure. It makes use of the local fractional derivative, which turns out to be a powerful tool to describe irregular patterns such as strain localization in heterogeneous materials. On the other hand, the latter is a non-local approach that models long-range interactions between particles by …

Continuum mechanicsOrder (ring theory)Fractional Calculus Fractals Local Fractional CalculusCommon denominatorCondensed Matter PhysicsNon localAtomic and Molecular Physics and OpticsFractional calculusQuantum mechanicsSolid mechanicsStatistical physicsSettore ICAR/08 - Scienza Delle CostruzioniMathematical PhysicsMathematicsPhysica Scripta
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Economic Freedom and its Measurement

2008

Interest in the measurement of economic freedom originates from two separate lines of inquiry. The first, firmly embedded in the tradition of normative economics, focuses on freedom measurement for enlarging the narrow evaluative bases of welfare economics. The second, rooted in the libertarian tradition, tries to construct objective empirical indices of the extent of economic freedom enjoyed by countries on a world-wide basis. Despite their different origins, methodology and aims, both traditions share a common denominator that informs their theoretical underpinnings and the measures that they construct, viz., individual choice. More precisely, economic freedom measures constructed within …

Economic freedomNormative economicsEconomicsCommon denominatorPolitical freedomFree marketPositive economicsConstruct (philosophy)
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Current trends in biocompatibility testing

1998

Biocompatibility remains the central theme for biomaterials applications in medicine. It is generally accepted that this term means not only absence of a cytotoxic effect but also positive effects in the sense of biofunctionality, i.e. promotion of biological processes which further the intended aim of the application of a biomaterial. The national and international standards for testing regimes represent a lowest common denominator for such applications and do not necessarily ensure that optimal function will be achieved. The authors' thesis is that biocompatibility testing has scope for extensive development with respect to biofunctionality. The present paper reviews current trends in the…

In Vitro TechniquesBiocompatibilitymedia_common.quotation_subjectCytological TechniquesBiocompatible MaterialsNanotechnologyIn Vitro TechniquesBiologyOrgan development03 medical and health sciences0302 clinical medicineMaterials TestingCell AdhesionMedical Laboratory ScienceAnimalsHumansLowest common denominatorFunction (engineering)Cells Culturedmedia_commonScope (project management)Mechanical EngineeringBiocompatibility TestingReproducibility of ResultsGeneral MedicineCytotoxicity Tests ImmunologicCritical appraisalRisk analysis (engineering)030220 oncology & carcinogenesisStress MechanicalRheology030217 neurology & neurosurgeryForecastingProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
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Serotonin dysfunction syndromes: a functional common denominator for classification of depression, anxiety, and obsessive-compulsive disorder.

1993

Psychiatric Status Rating Scalesmedicine.medical_specialtyDepressive DisorderObsessive-Compulsive DisorderSerotoninCommon denominatormedicine.diseaseAnxiety DisordersSerotonin Receptor AgonistsPsychiatry and Mental healthObsessive compulsiveReceptors SerotoninPsychiatric status rating scalesmedicineAnxietyHumansPharmacology (medical)SerotoninSerotonin Antagonistsmedicine.symptomPsychiatryPsychologyAnxiety disorderDepression (differential diagnoses)Selective Serotonin Reuptake InhibitorsInternational clinical psychopharmacology
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How To Combine Ozone Therapies With Other Modalities For Maximum Efficacy

2018

In order to use Bio-Oxidative Therapies effectively, a small shift in thinking is needed. One needs to shift from Disease Literacy to Healing Literacy This shift in thinking leads to the inevitable conclusion that: Impaired Oxygen Signaling is the common denominator for all disease. Impaired Oxygen Signaling affects: •                    O2 driven energetics •                    O2's detergent function •                    O2's cellular repair function •                    O2's renewal function  It is important to be aware of Oxygen's multiple functions in order to appreciate the importance of the role bio-oxidative therapies play in the reversal of disease conditions. In fact, no treatment…

Renewal functionmedicine.medical_specialtyModalitiesChronic diseasebusiness.industryOxygen metabolismmedicineCommon denominatorDiseaseIntensive care medicineDisease manifestationbusinessJournal of Ozone Therapy
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Narrativa dei Caraibi nel nuovo millennio

2020

L’etichetta “Letterature franco-caraibica” utilizzata, per convenzione, dalla critica per indicare unitariamente la produzione letteraria in lingua francese della regione centrale del Continente americano è assai impropria. La regione dei Caraibi abbraccia, infatti, sia alcune delle isole dell’arcipelago delle Piccole Antille (Martinica, Guadalupa), sia l’isola di Haïti, che fa parte delle Grandi Antille, che la Guiana incastonata sulla costa orientale dell’America meridionale. Pur nella diversità dei movimenti ideologici e degli avvenimenti storici che si sono succeduti nella regione, le opere letterarie degli scrittori caraibici francofoni, nel loro insieme, hanno oscillato, e continuano …

The definition "Franco-Caribbean Literature" used by convention from the critique to indicate all the literary production in French of the central region of the American continent is very improper. The Caribbean region includes in fact the islands of Martinique Guadeloupe Haïti and the Guiana. Despite the diversity of ideological movements and historical events that took place in these countries the literary works of the Caribbean writers have fluctuated and continue to oscillate between two tendencies: that of rooting in tradition and that of escape from it. The writers show themselves open to comparison and dialogue with other literary and cultural traditions in order to create a narrative form that corresponds to the many inheritances of those composite populations. Here the cultural syncretism that has been created allows to recognize a common identity in the name of all that the West wanted to extinguish. The common denominator seems to be inverted in the contradictory result of courageous but dangerous encounters of curiosities that can lead to conflicts to exclusions.
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Caraibi: un "archipel inachevé"

2018

L’etichetta “Letterature franco-caraibica” utilizzata, per convenzione, dalla critica per indicare unitariamente la produzione letteraria in lingua francese della regione centrale del Continente americano è assai impropria. La regione dei Caraibi abbraccia, infatti, sia alcune delle isole dell’arcipelago delle Piccole Antille (Martinica, Guadalupa), sia l’isola di Haïti, che fa parte delle Grandi Antille, che la Guiana incastonata sulla costa orientale dell’America meridionale. Pur nella diversità dei movimenti ideologici e degli avvenimenti storici che si sono succeduti nella regione, le opere letterarie degli scrittori caraibici francofoni, nel loro insieme, hanno oscillato, e continuano …

The definition "Franco-Caribbean Literature" used by convention from the critique to indicate all the literary production in French of the central region of the American continent is very improper. The Caribbean region includes in fact the islands of Martinique Guadeloupe Haïti and the Guiana. Despite the diversity of ideological movements and historical events that took place in these countries the literary works of the Caribbean writers have fluctuated and continue to oscillate between two tendencies: that of rooting in tradition and that of escape from it. The writers show themselves open to comparison and dialogue with other literary and cultural traditions in order to create a narrative form that corresponds to the many inheritances of those composite populations. Here the cultural syncretism that has been created allows to recognize a common identity in the name of all that the West wanted to extinguish. The common denominator seems to be inverted in the contradictory result of courageous but dangerous encounters of curiosities that can lead to conflicts to exclusions.Settore L-FIL-LET/14 - Critica Letteraria E Letterature Comparate
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The tangible common denominator of substance use disorders: a reply to commentaries to Rehm et al. (2013a)

2014

In response to our suggestion to define substance use disorders via ‘heavy use over time’, theoretical and conceptual issues, measurement problems and implications for stigma and clinical practice were raised. With respect to theoretical and conceptual issues, no other criterion has been shown, which would improve the definition. Moreover, heavy use over time is shown to be highly correlated with number of criteria in current DSM-5. Measurement of heavy use over time is simple and while there will be some underestimation or misrepresentation of actual levels in clinical practice, this is not different from the status quo and measurement of current criteria. As regards to stigma, research ha…

Time FactorsSubstance-Related DisordersStatus quomedia_common.quotation_subjectSocial StigmaCommon denominatorGeneral Medicinemedicine.diseaseDiagnostic and Statistical Manual of Mental DisordersSubstance abuseClinical PracticeMisrepresentationmedicineHumansSubstance usePsychologySocial psychologymedia_common
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Role of fungus in eosinophilic sinusitis.

2005

Chronic rhinosinusitis is characterized by a broad diagnostic and etiologic spectrum. It has been postulated that fungal organisms might represent the immunologic target initiating and maintaining the disease process in patients with chronic rhinosinusitis as a common denominator. This review analyzes the available data to describe the current understanding of the role of fungus in the pathophysiology of chronic rhinosinusitis.Recent findings have demonstrated that using highly sensitive methods, the detection rate of fungi in nasal mucin can be increased to approximately 100% in patients and in healthy controls. If this ubiquitous fungal contamination were to be related to a causative mech…

medicine.medical_specialtyChronic rhinosinusitisFungusEosinophilicEosinophiliaMedicineHumansDisease processIn patientSinusitisSinusitisRhinitisbiologybusiness.industryFungiCommon denominatormedicine.diseasebiology.organism_classificationDermatologyNasal MucosaChronic diseaseOtorhinolaryngologyMycosesChronic DiseaseSurgeryNasal CavitybusinessCurrent opinion in otolaryngologyhead and neck surgery
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